How to use the simulator
- Bar chart. Three bars show the expected genotype frequencies for AA, Aa (heterozygote) and aa, each labelled with its value. The y-axis (genotype frequency) runs from 0 to 1.
- Readout box. Lists p (freq. of A) and q (freq. of a) to two decimal places, then p2 AA, 2pq Aa and q2 aa to three decimal places.
- Check line. Under the readout, a line confirms that and for every slider position.
The equations
- is the frequency of the dominant allele and is the frequency of the recessive allele.
- is the frequency of homozygous dominant individuals (AA).
- is the frequency of heterozygotes (Aa). The factor of 2 is there because a heterozygote can get A from the mother and a from the father, or the other way round.
- is the frequency of homozygous recessive individuals (aa).
- No mutation
- Random mating
- No natural selection
- Extremely large population size (no genetic drift)
- No gene flow (no migration in or out)
Worked example
Check: .
AA:
Aa:
aa:
Total: .
Common mistakes on the AP exam
- Taking the square root of the dominant phenotype. The dominant phenotype is , not , so does not give . Always start from , the recessive phenotype.
- Mixing up q and q2. If a problem says 9% of individuals are aa, then and , not 0.09. If it says the allele frequency is 0.09, then .
- Forgetting the 2 in 2pq. Using for heterozygotes makes the three genotype frequencies add up to less than 1. Check that they sum to 1, just as the simulator's check line does.
- Answering in percent or counts when a frequency is asked for (or the reverse). Read the question for "frequency," "percentage" or "number of individuals" and give that form.
- Assuming equilibrium without being told to. If observed genotype counts are given, compare them with the Hardy-Weinberg expectation. A mismatch means at least one condition is being violated.
- Naming a condition vaguely. "The population is not ideal" earns nothing. Name the specific condition (for example, nonrandom mating) and explain how it would change allele or genotype frequencies.